| Reaction Details |
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 | Report a problem with these data |
| Target | Lysophosphatidic acid receptor 1 |
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| Ligand | BDBM50023473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452484 (CHEMBL3362833) |
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| IC50 | 74±n/a nM |
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| Citation |  Sidduri, A; Budd, DC; Fuentes, ME; Lambros, T; Ren, Y; Roongta, V; Schoenfeld, RC; Gillespie, P; Stevenson, CS; Truitt, T; Qian, Y Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists. Bioorg Med Chem Lett24:4450-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysophosphatidic acid receptor 1 |
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| Name: | Lysophosphatidic acid receptor 1 |
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| Synonyms: | EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41120.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92633 |
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| Residue: | 364 |
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| Sequence: | MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV
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| BDBM50023473 |
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| n/a |
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| Name | BDBM50023473 |
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| Synonyms: | CHEMBL3326527 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18FN5O2 |
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| Mol. Mass. | 355.3662 |
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| SMILES | COc1ccc(C(=O)C(=N/C2CCCC2)\n2ncc(C#N)c2N)c(F)c1 |
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| Structure | 
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