| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proteinase-activated receptor 4 |
|---|
| Ligand | BDBM50024252 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1435253 (CHEMBL3390699) |
|---|
| IC50 | 140±n/a nM |
|---|
| Citation |  Wen, W; Young, SE; Duvernay, MT; Schulte, ML; Nance, KD; Melancon, BJ; Engers, J; Locuson, CW; Wood, MR; Daniels, JS; Wu, W; Lindsley, CW; Hamm, HE; Stauffer, SR Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett24:4708-13 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proteinase-activated receptor 4 |
|---|
| Name: | Proteinase-activated receptor 4 |
|---|
| Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 41145.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96RI0 |
|---|
| Residue: | 385 |
|---|
| Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
|
|
|
|---|
| BDBM50024252 |
|---|
| n/a |
|---|
| Name | BDBM50024252 |
|---|
| Synonyms: | CHEMBL1609104 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H14N2O3 |
|---|
| Mol. Mass. | 282.294 |
|---|
| SMILES | Cn1c(CO)c(-c2ccccc2)c2cc(ccc12)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
