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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 4-hydroxyphenylpyruvate dioxygenase | ||
| Ligand | BDBM50024726 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1438115 (CHEMBL3388490) | ||
| Ki | 22±n/a nM | ||
| Citation |  Xu, YL; Lin, HY; Cao, RJ; Ming, ZZ; Yang, WC; Yang, GF Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Bioorg Med Chem22:5194-211 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 4-hydroxyphenylpyruvate dioxygenase | |||
| Name: | 4-hydroxyphenylpyruvate dioxygenase | ||
| Synonyms: | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_HUMAN | PPD | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 44937.33 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_123 | ||
| Residue: | 393 | ||
| Sequence: |
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| BDBM50024726 | |||
| n/a | |||
| Name | BDBM50024726 | ||
| Synonyms: | CHEMBL3342598 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H15ClN4O3 | ||
| Mol. Mass. | 394.811 | ||
| SMILES | Cc1nc2ccc(cc2c(=O)n1-c1ccccc1Cl)C(=O)c1cnn(C)c1O |(39.95,-6.5,;38.6,-5.76,;37.27,-6.56,;35.91,-5.82,;34.6,-6.61,;33.25,-5.87,;33.22,-4.32,;34.53,-3.53,;35.88,-4.27,;37.2,-3.46,;37.16,-1.92,;38.56,-4.21,;39.88,-3.41,;39.83,-1.87,;41.14,-1.07,;42.5,-1.81,;42.54,-3.35,;41.22,-4.15,;41.25,-5.69,;31.87,-3.58,;31.84,-2.04,;30.55,-4.38,;30.42,-5.91,;28.92,-6.27,;28.13,-4.95,;26.6,-4.82,;29.13,-3.78,;28.78,-2.28,)| | ||
| Structure | 
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