| Reaction Details |
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 | Report a problem with these data |
| Target | 4-hydroxyphenylpyruvate dioxygenase |
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| Ligand | BDBM50088804 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1438115 (CHEMBL3388490) |
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| Ki | 37±n/a nM |
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| Citation |  Xu, YL; Lin, HY; Cao, RJ; Ming, ZZ; Yang, WC; Yang, GF Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Bioorg Med Chem22:5194-211 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 4-hydroxyphenylpyruvate dioxygenase |
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| Name: | 4-hydroxyphenylpyruvate dioxygenase |
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| Synonyms: | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_HUMAN | PPD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44937.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_123 |
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| Residue: | 393 |
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| Sequence: | MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSH
VIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMRE
PWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEM
IDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPI
NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLR
EKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFG
AGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
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| BDBM50088804 |
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| n/a |
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| Name | BDBM50088804 |
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| Synonyms: | 1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethyl)benzoyl)- | 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione | 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione | CHEMBL1337 | NITISINONE |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10F3NO5 |
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| Mol. Mass. | 329.2281 |
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| SMILES | [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F |
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| Structure | 
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