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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 4-hydroxyphenylpyruvate dioxygenase | ||
| Ligand | BDBM50024748 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1438115 (CHEMBL3388490) | ||
| Ki | 59±n/a nM | ||
| Citation |  Xu, YL; Lin, HY; Cao, RJ; Ming, ZZ; Yang, WC; Yang, GF Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Bioorg Med Chem22:5194-211 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 4-hydroxyphenylpyruvate dioxygenase | |||
| Name: | 4-hydroxyphenylpyruvate dioxygenase | ||
| Synonyms: | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_HUMAN | PPD | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 44937.33 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_123 | ||
| Residue: | 393 | ||
| Sequence: |
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| BDBM50024748 | |||
| n/a | |||
| Name | BDBM50024748 | ||
| Synonyms: | CHEMBL3343187 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H20N4O3 | ||
| Mol. Mass. | 388.4192 | ||
| SMILES | Cc1ccc(c(C)c1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O |(30.83,-34.46,;29.51,-35.26,;29.55,-36.8,;28.23,-37.6,;26.89,-36.85,;26.84,-35.32,;25.49,-34.58,;28.16,-34.52,;25.57,-37.65,;25.61,-39.2,;26.96,-39.95,;24.28,-40.01,;22.92,-39.26,;21.61,-40.06,;20.26,-39.31,;20.23,-37.77,;21.54,-36.98,;22.89,-37.71,;24.21,-36.9,;24.17,-35.36,;18.88,-37.03,;18.85,-35.49,;17.57,-37.82,;17.43,-39.36,;15.94,-39.71,;15.14,-38.39,;13.61,-38.27,;16.14,-37.23,;15.79,-35.73,)| | ||
| Structure | 
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