| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
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| Ligand | BDBM50025021 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440401 (CHEMBL3386214) |
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| IC50 | 620±n/a nM |
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| Citation |  Richter, J; Bischof, J; Zaja, M; Kohlhof, H; Othersen, O; Vitt, D; Alscher, V; Pospiech, I; García-Reyes, B; Berg, S; Leban, J; Knippschild, U Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1d ande with nanomolar inhibitory activity on cancer cell proliferation. J Med Chem57:7933-46 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform epsilon |
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| Name: | Casein kinase I isoform epsilon |
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| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1ÆÂ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47340.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49674 |
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| Residue: | 416 |
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| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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| BDBM50025021 |
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| n/a |
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| Name | BDBM50025021 |
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| Synonyms: | CHEMBL3337853 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H9F2N7O3 |
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| Mol. Mass. | 385.2846 |
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| SMILES | FC1(F)Oc2cc3nc(NC(=O)c4cccc(c4)-c4nnn[nH]4)[nH]c3cc2O1 |
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| Structure | 
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