| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform delta |
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| Ligand | BDBM50025020 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440400 (CHEMBL3386213) |
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| IC50 | 40±n/a nM |
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| Citation |  Richter, J; Bischof, J; Zaja, M; Kohlhof, H; Othersen, O; Vitt, D; Alscher, V; Pospiech, I; García-Reyes, B; Berg, S; Leban, J; Knippschild, U Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1d ande with nanomolar inhibitory activity on cancer cell proliferation. J Med Chem57:7933-46 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform delta |
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| Name: | Casein kinase I isoform delta |
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| Synonyms: | CK1, delta | Casein kinase 1 Delta | Casein kinase I delta | Casein kinase I isoform delta | Csnk1d | Hckid | KC1D_RAT | casein kinase 1, delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 47342.73 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q06486 |
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| Residue: | 415 |
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| Sequence: | MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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| BDBM50025020 |
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| n/a |
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| Name | BDBM50025020 |
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| Synonyms: | CHEMBL3337854 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H11F6N5O3S |
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| Mol. Mass. | 515.388 |
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| SMILES | FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2ccc(cc2[nH]1)C(F)(F)F |
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| Structure | 
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