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Reaction Details
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TargetProstanoid TP receptor
LigandBDBM50026753
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1437451
IC50 16±n/a nM
Citation Wang XLiu LHuang LHerbst-Robinson KCornec ASJames MJSugiyama SBassetto MBrancale ATrojanowski JQLee VMSmith ABBrunden KRBallatore C Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med Chem Lett 5:1015-20 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostanoid TP receptor
Name:Thromboxane A2 receptor
Synonyms:TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:Enyzme
Mol. Mass.:37445.28
Organism:Homo sapiens (Human)
Description:P21731
Residue:343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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  Blast E-value cutoff:
BDBM50026753
n/a
NameBDBM50026753
Synonyms:S-18886 | TERUTROBAN | Terutroban
TypeSmall organic molecule
Emp. Form.C20H22ClNO4S
Mol. Mass.407.911
SMILESCc1ccc2C[C@@H](CCc2c1CCC(O)=O)NS(=O)(=O)c1ccc(Cl)cc1 |r|
Structure
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