Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50026757 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1437451 (CHEMBL3387261) |
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IC50 | 892±n/a nM |
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Citation | Wang, X; Liu, L; Huang, L; Herbst-Robinson, K; Cornec, AS; James, MJ; Sugiyama, S; Bassetto, M; Brancale, A; Trojanowski, JQ; Lee, VM; Smith, AB; Brunden, KR; Ballatore, C Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med Chem Lett5:1015-20 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50026757 |
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n/a |
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Name | BDBM50026757 |
Synonyms: | CHEMBL3335483 |
Type | Small organic molecule |
Emp. Form. | C26H30ClNO4S |
Mol. Mass. | 488.039 |
SMILES | OC1=C(C2CCCCC2)C(=O)C(Cc2cccc(CCNS(=O)(=O)c3ccc(Cl)cc3)c2)C1 |c:1| |
Structure |
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