| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 11 |
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| Ligand | BDBM50027649 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1443006 (CHEMBL3379484) |
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| IC50 | 9.0±n/a nM |
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| Citation |  Giannini, G; Vesci, L; Battistuzzi, G; Vignola, D; Milazzo, FM; Guglielmi, MB; Barbarino, M; Santaniello, M; Fantò, N; Mor, M; Rivara, S; Pala, D; Taddei, M; Pisano, C; Cabri, W ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors. J Med Chem57:8358-77 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 11 |
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| Name: | Histone deacetylase 11 |
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| Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 39187.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96DB2 |
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| Residue: | 347 |
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| Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
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| BDBM50027649 |
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| n/a |
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| Name | BDBM50027649 |
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| Synonyms: | CHEMBL3356527 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27N3O3S |
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| Mol. Mass. | 377.501 |
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| SMILES | SCCCCC[C@H](NC(=O)[C@@H]1CCCNC1=O)C(=O)Nc1ccccc1 |r| |
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| Structure | 
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