| Reaction Details |
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 | Report a problem with these data |
| Target | Proton-coupled folate transporter |
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| Ligand | BDBM50027658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1431349 (CHEMBL3387475) |
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| IC50 | >1000±n/a nM |
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| Citation |  Golani, LK; George, C; Zhao, S; Raghavan, S; Orr, S; Wallace, A; Wilson, MR; Hou, Z; Matherly, LH; Gangjee, A Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. J Med Chem57:8152-66 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proton-coupled folate transporter |
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| Name: | Proton-coupled folate transporter |
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| Synonyms: | G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49782.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469597 |
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| Residue: | 459 |
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| Sequence: | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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| BDBM50027658 |
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| n/a |
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| Name | BDBM50027658 |
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| Synonyms: | CHEMBL3335606 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N5O4S |
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| Mol. Mass. | 403.455 |
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| SMILES | Nc1nc2[nH]c(CCCc3ccc(s3)C(=O)NCCCC(O)=O)cc2c(=O)[nH]1 |
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| Structure | 
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