Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetFolate receptor beta
LigandBDBM18050
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1431348 (CHEMBL3387474)
IC50 211±n/a nM
Citation Golani, LKGeorge, CZhao, SRaghavan, SOrr, SWallace, AWilson, MRHou, ZMatherly, LHGangjee, A Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. J Med Chem57:8152-66 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Folate receptor beta
Name:Folate receptor beta
Synonyms:FBP | FOLR2 | FOLR2_HUMAN | FR-beta | Folate receptor 2 | Folate receptor beta | Folate receptor, fetal/placental | Placental folate-binding protein
Type:PROTEIN
Mol. Mass.:29286.32
Organism:Homo sapiens (Human)
Description:ChEMBL_20077
Residue:255
Sequence:
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACC
TASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRK
ERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPA
ALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGG
LLLSLALMLQLWLLG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM18050
n/a
NameBDBM18050
Synonyms:2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid | CHEMBL34259 | MTX | Methotrexate | cid_126941
TypeSmall organic molecule
Emp. Form.C20H22N8O5
Mol. Mass.454.4393
SMILESCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: