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TargetFolate receptor alpha
LigandBDBM50027655
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1431345 (CHEMBL3387471)
IC50 15±n/a nM
Citation Golani, LKGeorge, CZhao, SRaghavan, SOrr, SWallace, AWilson, MRHou, ZMatherly, LHGangjee, A Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. J Med Chem57:8152-66 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Folate receptor alpha
Name:Folate receptor alpha
Synonyms:Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
Type:PROTEIN
Mol. Mass.:29827.41
Organism:Homo sapiens (Human)
Description:ChEMBL_1469596
Residue:257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPW
RKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQV
DQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHF
YFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWA
AWPFLLSLALMLLWLLS
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  Blast E-value cutoff:
BDBM50027655
n/a
NameBDBM50027655
Synonyms:CHEBI:5847 | Raltitrexed | Tomudex | US9422297, Raltitrexed | ZD-16 | ZD-1694
TypeSmall organic molecule
Emp. Form.C21H22N4O6S
Mol. Mass.458.488
SMILESCN(Cc1ccc2[nH]c(C)nc(=O)c2c1)c1ccc(s1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure
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