Reaction Details |
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Target | Folate receptor alpha |
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Ligand | BDBM50027655 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1431345 (CHEMBL3387471) |
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IC50 | 15±n/a nM |
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Citation | Golani, LK; George, C; Zhao, S; Raghavan, S; Orr, S; Wallace, A; Wilson, MR; Hou, Z; Matherly, LH; Gangjee, A Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. J Med Chem57:8152-66 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Folate receptor alpha |
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Name: | Folate receptor alpha |
Synonyms: | Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18 |
Type: | PROTEIN |
Mol. Mass.: | 29827.41 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469596 |
Residue: | 257 |
Sequence: | MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPW
RKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQV
DQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHF
YFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWA
AWPFLLSLALMLLWLLS
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BDBM50027655 |
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n/a |
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Name | BDBM50027655 |
Synonyms: | CHEBI:5847 | Raltitrexed | Tomudex | US9422297, Raltitrexed | ZD-16 | ZD-1694 |
Type | Small organic molecule |
Emp. Form. | C21H22N4O6S |
Mol. Mass. | 458.488 |
SMILES | CN(Cc1ccc2[nH]c(C)nc(=O)c2c1)c1ccc(s1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
Structure |
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