Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetReduced folate transporter
LigandBDBM50027656
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1431343 (CHEMBL3387469)
IC50 138±n/a nM
Citation Golani, LKGeorge, CZhao, SRaghavan, SOrr, SWallace, AWilson, MRHou, ZMatherly, LHGangjee, A Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. J Med Chem57:8152-66 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Reduced folate transporter
Name:Reduced folate transporter
Synonyms:FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | S19A1_HUMAN | SLC19A1 | Solute carrier family 19 member 1
Type:PROTEIN
Mol. Mass.:64885.16
Organism:Homo sapiens (Human)
Description:ChEMBL_1469594
Residue:591
Sequence:
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50027656
n/a
NameBDBM50027656
Synonyms:CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | US9422297, Pemetrexed
TypeSmall organic molecule
Emp. Form.C20H21N5O6
Mol. Mass.427.4106
SMILESNc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: