Reaction Details |
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Target | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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Ligand | BDBM50027688 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1435383 (CHEMBL3383457) |
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Ki | 230±n/a nM |
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Citation | Ferla, S; Gomaa, MS; Brancale, A; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation. Eur J Med Chem87:39-51 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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Name: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
Synonyms: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1 |
Type: | Protein |
Mol. Mass.: | 58889.66 |
Organism: | Homo sapiens (Human) |
Description: | Q07973 |
Residue: | 514 |
Sequence: | MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
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BDBM50027688 |
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n/a |
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Name | BDBM50027688 |
Synonyms: | CHEMBL3344400 |
Type | Small organic molecule |
Emp. Form. | C27H28N2O2S |
Mol. Mass. | 444.588 |
SMILES | Cc1ccc(cc1)S(=O)(=O)NCCCCn1ccc2c(\C=C\c3ccccc3)cccc12 |
Structure |
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