| Reaction Details |
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 | Report a problem with these data |
| Target | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Ligand | BDBM50027694 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1435384 (CHEMBL3383458) |
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| Ki | 24±n/a nM |
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| Citation |  Ferla, S; Gomaa, MS; Brancale, A; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation. Eur J Med Chem87:39-51 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Name: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Synonyms: | 25-OHD-1 alpha-hydroxylase | 25-hydroxyvitamin D(3) 1-alpha-hydroxylase | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_MOUSE | Calcidiol 1-monooxygenase | Cyp27b | Cyp27b | Cyp27b1 | Cyp40 | Cytochrome P450 subfamily XXVIIB polypeptide 1 | Cytochrome P450C1 alpha | Cytochrome P450VD1-alpha | Cytochrome p450 27B1 | VD3 1A hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56238.51 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109473 |
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| Residue: | 507 |
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| Sequence: | MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSR
LHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRH
QRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLP
GLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPN
WLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFRE
KVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHG
TALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQ
FPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPE
PGALPIKPMTRTVLVPERSINLQFVDR
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| BDBM50027694 |
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| n/a |
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| Name | BDBM50027694 |
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| Synonyms: | CHEMBL3344397 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N3 |
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| Mol. Mass. | 341.4488 |
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| SMILES | C(CCn1ccc2cc(\C=C\c3ccccc3)ccc12)Cn1ccnc1 |
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| Structure | 
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