| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase N1 |
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| Ligand | BDBM50028033 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1433150 (CHEMBL3387550) |
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| IC50 | 99±n/a nM |
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| Citation |  Shaw, D; Hollingworth, G; Soldermann, N; Sprague, E; Schuler, W; Vangrevelinghe, E; Duggan, N; Thomas, M; Kosaka, T; Waters, N; van Eis, MJ Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Bioorg Med Chem Lett24:4812-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase N1 |
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| Name: | Serine/threonine-protein kinase N1 |
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| Synonyms: | PAK1 | PKN | PKN1 | PKN1_HUMAN | PRK1 | PRKCL1 | Protein kinase N1 | Serine/threonine-protein kinase N1/Transforming protein RhoA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103928.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1433150 |
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| Residue: | 942 |
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| Sequence: | MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLR
RATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTC
SATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDII
RMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLS
AAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAF
STRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPF
LSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFT
LELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPV
IERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGS
EARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPA
LCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESL
MCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFY
SACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPE
FLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSA
EAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD
VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
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| BDBM50028033 |
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| n/a |
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| Name | BDBM50028033 |
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| Synonyms: | CHEMBL3338837 | US11458138, Example 312 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N6 |
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| Mol. Mass. | 294.3543 |
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| SMILES | CC(C)(N)CNc1nc(nc2cnccc12)-c1ccncc1 |
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| Structure | 
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