| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase N2 |
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| Ligand | BDBM50324316 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1433151 (CHEMBL3387551) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Shaw, D; Hollingworth, G; Soldermann, N; Sprague, E; Schuler, W; Vangrevelinghe, E; Duggan, N; Thomas, M; Kosaka, T; Waters, N; van Eis, MJ Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Bioorg Med Chem Lett24:4812-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase N2 |
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| Name: | Serine/threonine-protein kinase N2 |
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| Synonyms: | PKN2 | PKN2_HUMAN | PRK2 | PRKCL2 | Protein kinase C-like 2 | Protein kinase N2 | Protein-kinase C-related kinase 2 | Serine/threonine-protein kinase N2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 112029.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1433151 |
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| Residue: | 984 |
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| Sequence: | MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL
KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL
QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM
KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS
PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK
FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV
PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG
QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL
VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY
RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL
GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP
REPRILSEEEQEMFRDFDYIADWC
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| BDBM50324316 |
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| n/a |
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| Name | BDBM50324316 |
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| Synonyms: | CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-1,2-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15N5 |
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| Mol. Mass. | 265.3131 |
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| SMILES | NCCNc1nc(cc2cnccc12)-c1ccncc1 |
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| Structure | 
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