Reaction Details |
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Target | Serine/threonine-protein kinase N2 |
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Ligand | BDBM50324316 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1433151 (CHEMBL3387551) |
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IC50 | 7.0±n/a nM |
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Citation | Shaw, D; Hollingworth, G; Soldermann, N; Sprague, E; Schuler, W; Vangrevelinghe, E; Duggan, N; Thomas, M; Kosaka, T; Waters, N; van Eis, MJ Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Bioorg Med Chem Lett24:4812-7 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase N2 |
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Name: | Serine/threonine-protein kinase N2 |
Synonyms: | PKN2 | PKN2_HUMAN | PRK2 | PRKCL2 | Protein kinase C-like 2 | Protein kinase N2 | Protein-kinase C-related kinase 2 | Serine/threonine-protein kinase N2 |
Type: | PROTEIN |
Mol. Mass.: | 112029.78 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1433151 |
Residue: | 984 |
Sequence: | MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL
KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL
QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM
KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS
PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK
FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV
PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG
QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL
VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY
RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL
GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP
REPRILSEEEQEMFRDFDYIADWC
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BDBM50324316 |
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n/a |
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Name | BDBM50324316 |
Synonyms: | CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-1,2-diamine |
Type | Small organic molecule |
Emp. Form. | C15H15N5 |
Mol. Mass. | 265.3131 |
SMILES | NCCNc1nc(cc2cnccc12)-c1ccncc1 |
Structure |
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