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TargetSerine/threonine-protein kinase N2
LigandBDBM50028035
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1433151 (CHEMBL3387551)
IC50 974±n/a nM
Citation Shaw, DHollingworth, GSoldermann, NSprague, ESchuler, WVangrevelinghe, EDuggan, NThomas, MKosaka, TWaters, Nvan Eis, MJ Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Bioorg Med Chem Lett24:4812-7 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase N2
Name:Serine/threonine-protein kinase N2
Synonyms:PKN2 | PKN2_HUMAN | PRK2 | PRKCL2 | Protein kinase C-like 2 | Protein kinase N2 | Protein-kinase C-related kinase 2 | Serine/threonine-protein kinase N2
Type:PROTEIN
Mol. Mass.:112029.78
Organism:Homo sapiens (Human)
Description:ChEMBL_1433151
Residue:984
Sequence:
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL
KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL
QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM
KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS
PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK
FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV
PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG
QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL
VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY
RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL
GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP
REPRILSEEEQEMFRDFDYIADWC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50028035
n/a
NameBDBM50028035
Synonyms:CHEMBL3338839
TypeSmall organic molecule
Emp. Form.C18H17N7
Mol. Mass.331.3745
SMILESC1CN(CCN1)c1nc(nc2cnccc12)-c1ccc2[nH]ncc2c1
Structure
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