| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50028045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1433181 (CHEMBL3387581) |
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| IC50 | 14±n/a nM |
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| Citation |  Roecker, AJ; Reger, TS; Mattern, MC; Mercer, SP; Bergman, JM; Schreier, JD; Cube, RV; Cox, CD; Li, D; Lemaire, W; Bruno, JG; Harrell, CM; Garson, SL; Gotter, AL; Fox, SV; Stevens, J; Tannenbaum, PL; Prueksaritanont, T; Cabalu, TD; Cui, D; Stellabott, J; Hartman, GD; Young, SD; Winrow, CJ; Renger, JJ; Coleman, PJ Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Bioorg Med Chem Lett24:4884-90 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50028045 |
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| n/a |
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| Name | BDBM50028045 |
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| Synonyms: | CHEMBL3338852 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N3O3 |
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| Mol. Mass. | 439.5057 |
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| SMILES | COc1ccc(CNC(=O)c2cc(ccc2-c2ccccc2)-c2cncc(C)c2)nc1OC |
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| Structure | 
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