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TargetTranscription intermediary factor 1-alpha
LigandBDBM50028142
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1434764 (CHEMBL3383433)
IC50 15849±n/a nM
Citation Gosmini, RNguyen, VLToum, JSimon, CBrusq, JMKrysa, GMirguet, ORiou-Eymard, AMBoursier, EVTrottet, LBamborough, PClark, HChung, CWCutler, LDemont, EHKaur, RLewis, AJSchilling, MBSoden, PETaylor, SWalker, ALWalker, MDPrinjha, RKNicodème, E The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor. J Med Chem57:8111-31 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcription intermediary factor 1-alpha
Name:Transcription intermediary factor 1-alpha
Synonyms:6.3.2.- | E3 ubiquitin-protein ligase TRIM24 | RING finger protein 82 | RNF82 | RNF82 | TIF1 | TIF1-alpha | TIF1A | TIF1A_HUMAN | TRIM24 | Transcription intermediary factor 1-alpha | Tripartite motif-containing protein 24
Type:PROTEIN
Mol. Mass.:116839.55
Organism:Homo sapiens (Human)
Description:ChEMBL_107998
Residue:1050
Sequence:
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCH
QNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFAT
QVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDK
LTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQ
NQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINL
GSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQ
RQQVQRRPAPVGLPNPRMQGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRY
PPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYD
GKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQS
PNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPI
RIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRS
DAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLC
CEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKL
TPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYS
KPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESE
DNKFSDDSDDDFVQPRKKRLKSIEERQLLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50028142
n/a
NameBDBM50028142
Synonyms:CHEMBL2177300
TypeSmall organic molecule
Emp. Form.C25H23ClN2O3
Mol. Mass.434.915
SMILESC[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O |r|
Structure
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