Reaction Details |
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Target | Ceramide glucosyltransferase |
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Ligand | BDBM50028254 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1435474 (CHEMBL3384689) |
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IC50 | 3.0±n/a nM |
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Citation | Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. J Med Chem57:9096-104 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ceramide glucosyltransferase |
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Name: | Ceramide glucosyltransferase |
Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
Type: | PROTEIN |
Mol. Mass.: | 44859.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1435474 |
Residue: | 394 |
Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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BDBM50028254 |
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n/a |
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Name | BDBM50028254 |
Synonyms: | CHEMBL3354634 |
Type | Small organic molecule |
Emp. Form. | C25H32F3NO5 |
Mol. Mass. | 483.5205 |
SMILES | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1C(F)(F)F)-c1ccccc1 |r| |
Structure |
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