| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM5025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1437607 (CHEMBL3390209) |
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| IC50 | 13±n/a nM |
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| Citation |  Xie, Y; Xu, D; Huang, B; Ma, X; Qi, W; Shi, F; Liu, X; Zhang, Y; Xu, W Discovery of N-substituted oseltamivir derivatives as potent and selective inhibitors of H5N1 influenza neuraminidase. J Med Chem57:8445-58 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | NA | NRAM_I77AB | Neuraminidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51863.92 |
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| Organism: | Influenza A virus (strain A/USSR/90/1977 H1N1) |
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| Description: | ChEMBL_109720 |
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| Residue: | 470 |
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| Sequence: | MNPNQKIITIGSICMAIGIISLILQIGNIISIWVSHSIQTGSQNHTGICNQRIITYENST
WVNQTYVNISNTNVVAGKDTTSMTLAGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREP
FISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPIGEAPSPYNSRFESVAWS
ASACHDGMGWLTIGISGPDDGAVAVLKYNGIITETIKSWRKQILRTQESECVCVNGSCFT
IMTDGPSDGPASYRIFKIEKGKITKSIELDAPNSHYEECSCYPDTGTVMCVCRDNWHGSN
RPWVSFNQNLDYQIGYICSGVFGDNPRPKDGKGSCDPVNVDGADGVKGFSYRYGNGVWIG
RTKSNSSRKGFEMIWDPNGWTDTDSNFLVKQDVVAMTDWSGYSGSFVQHPELTGLDCMRP
CFWVELIRGRPREKTTIWTSGSSISFCGVNSDTVNWSWPDGAELPFTIDK
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| BDBM5025 |
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| n/a |
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| Name | BDBM5025 |
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| Synonyms: | Oseltamivir | US10919856, POSITIVE CONTROL | ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C16H28N2O4 |
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| Mol. Mass. | 312.4045 |
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| SMILES | [H][C@@]1(OC(CC)CC)C=C(C[C@H](N)[C@H]1NC(C)=O)C(=O)OCC |r,c:8| |
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| Structure | 
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