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TargetProstaglandin E synthase
LigandBDBM50099410
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1440625 (CHEMBL3389824)
IC50 5.0±n/a nM
Citation Banerjee, APawar, MYPatil, SYadav, PSKadam, PAKattige, VGDeshpande, DSPednekar, PVPisat, MKGharat, LA Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors. Bioorg Med Chem Lett24:4838-44 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase
Name:Prostaglandin E synthase
Synonyms:MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:Protein
Mol. Mass.:17112.22
Organism:Homo sapiens (Human)
Description:n/a
Residue:152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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  Blast E-value cutoff:
BDBM50099410
n/a
NameBDBM50099410
Synonyms:CHEMBL3342849
TypeSmall organic molecule
Emp. Form.C25H20ClF3N4O2
Mol. Mass.500.9
SMILESCC(C)C(=O)NCc1ccc(Cl)c(c1)-c1nc2cc(ncc2c(=O)[nH]1)-c1ccc(cc1)C(F)(F)F
Structure
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