| Reaction Details |
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 | Report a problem with these data |
| Target | Matrilysin |
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| Ligand | BDBM50265079 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1432369 (CHEMBL3384474) |
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| IC50 | >30000±n/a nM |
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| Citation |  Fabre, B; Ramos, A; de Pascual-Teresa, B Targeting matrix metalloproteinases: exploring the dynamics of the s1' pocket in the design of selective, small molecule inhibitors. J Med Chem57:10205-19 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrilysin |
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| Name: | Matrilysin |
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| Synonyms: | MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29681.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09237 |
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| Residue: | 267 |
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| Sequence: | MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD
PQNFKLSQDDIKGIQKLYGKRSNSRKK
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| BDBM50265079 |
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| n/a |
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| Name | BDBM50265079 |
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| Synonyms: | (4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-quinazolin-3-ylmethyl]-benzoic acid) | 4-((1-methyl-2,4-dioxo-6-(3-phenylprop-1-ynyl)-1,2-dihydroquinazolin-3(4H)-yl)methyl)benzoic acid | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CHEMBL496942 | MMP Inhibitor, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20N2O4 |
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| Mol. Mass. | 424.448 |
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| SMILES | Cn1c2ccc(cc2c(=O)n(Cc2ccc(cc2)C(O)=O)c1=O)C#CCc1ccccc1 |
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| Structure | 
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