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TargetGamma-butyrobetaine dioxygenase
LigandBDBM34233
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1434107
IC50 830±n/a nM
Citation Rydzik AMBrem JStruwe WBKochan GTBenesch JLSchofield CJ Ejection of structural zinc leads to inhibition of┐-butyrobetaine hydroxylase. Bioorg Med Chem Lett 24:4954-7 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gamma-butyrobetaine dioxygenase
Name:Gamma-butyrobetaine dioxygenase
Synonyms:BBH | BBOX | BBOX1 | Gamma-BBH | Gamma-butyrobetaine hydroxylase | Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Type:PROTEIN
Mol. Mass.:44715.93
Organism:Homo sapiens (Human)
Description:ChEMBL_1434107
Residue:387
Sequence:
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDV
NIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSEL
QLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHT
WQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQK
LKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIF
DVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISR
HLEGAYADWDVVMSRLRILRQRVENGN
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  Blast E-value cutoff:
BDBM34233
n/a
NameBDBM34233
Synonyms:2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebselen) | 2-phenyl-1,2-benzisoselazol-3(2H)-one | 2-phenyl-1,2-benzoselenazol-3-one | 2-phenylbenzo[d][1,2]selenazol-3(2H)-one | CHEMBL51085 | EBSELEN | Ebselen (C5) | MLS000028488 | SMR000058445 | cid_3194
TypeSmall organic molecule
Emp. Form.C13H9NOSe
Mol. Mass.274.18
SMILESO=c1n([se]c2ccccc12)-c1ccccc1
Structure
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