Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50029439 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1436941 (CHEMBL3388439) |
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IC50 | 783±n/a nM |
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Citation | Cai, J; Li, L; Hong, KH; Wu, X; Chen, J; Wang, P; Cao, M; Zong, X; Ji, M Discovery of 4-aminoquinazoline--urea derivatives as Aurora kinase inhibitors with antiproliferative activity. Bioorg Med Chem22:5813-23 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50029439 |
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n/a |
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Name | BDBM50029439 |
Synonyms: | CHEMBL3343317 |
Type | Small organic molecule |
Emp. Form. | C31H38N6O3 |
Mol. Mass. | 542.6718 |
SMILES | OCC1CCN(CCCOC2=CC3N=CN=C(Nc4ccc(NC(=O)NCc5ccccc5)cc4)C3C=C2)CC1 |c:13,39,t:10,15| |
Structure |
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