Ki Summary

Reaction Details

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Target

Cannabinoid receptor 2

Ligand

BDBM50029924

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1438384 (CHEMBL3383059)

IC50

210±n/a nM

Citation

Lucchesi, V; Hurst, DP; Shore, DM; Bertini, S; Ehrmann, BM; Allar�, M; Lawrence, L; Ligresti, A; Minutolo, F; Saccomanni, G; Sharir, H; Macchia, M; Di Marzo, V; Abood, ME; Reggio, PH; Manera, C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem57:8777-91 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

39690.94

Organism:

Homo sapiens (Human)

Description:

P34972

Residue:

360

Sequence:

MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

BDBM50029924

n/a

Name

BDBM50029924

Synonyms:

CHEMBL3353427

Type

Small organic molecule

Emp. Form.

C20H27N3O3

Mol. Mass.

357.4467

SMILES

CC1CCC(CC1)NC(=O)c1cc2cccnc2n(CCCCO)c1=O |(22.97,-9.81,;21.64,-10.59,;21.64,-12.13,;20.31,-12.9,;18.97,-12.13,;18.96,-10.6,;20.3,-9.82,;17.64,-12.91,;16.3,-12.14,;16.3,-10.6,;14.98,-12.92,;13.64,-12.16,;12.31,-12.94,;10.98,-12.17,;9.65,-12.94,;9.65,-14.49,;10.98,-15.26,;12.31,-14.48,;13.65,-15.25,;13.65,-16.79,;14.99,-17.55,;16.32,-16.78,;17.66,-17.55,;18.99,-16.77,;14.98,-14.47,;16.32,-15.24,)|

Structure