Ki Summary

Reaction Details

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Target

Cannabinoid receptor 2

Ligand

BDBM50030084

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1438384 (CHEMBL3383059)

176±n/a nM

Citation

Lucchesi, V; Hurst, DP; Shore, DM; Bertini, S; Ehrmann, BM; Allar�, M; Lawrence, L; Ligresti, A; Minutolo, F; Saccomanni, G; Sharir, H; Macchia, M; Di Marzo, V; Abood, ME; Reggio, PH; Manera, C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem57:8777-91 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

39690.94

Organism:

Homo sapiens (Human)

Description:

P34972

Residue:

360

Sequence:

MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

BDBM50030084

n/a

Name

BDBM50030084

Synonyms:

CHEMBL3353430

Type

Small organic molecule

Emp. Form.

C21H27N3O4

Mol. Mass.

385.4568

SMILES

CCOC(=O)CCn1c2ncccc2cc(C(=O)NC2CCC(C)CC2)c1=O |(14.41,-27,;14.41,-28.54,;15.74,-29.31,;17.08,-28.54,;18.41,-29.3,;17.07,-27,;15.74,-26.23,;15.73,-24.69,;14.4,-23.92,;13.07,-24.7,;11.73,-23.93,;11.73,-22.38,;13.06,-21.61,;14.4,-22.38,;15.72,-21.6,;17.06,-22.36,;18.39,-21.59,;18.38,-20.05,;19.73,-22.35,;21.06,-21.57,;22.4,-22.34,;23.72,-21.57,;23.72,-20.03,;25.05,-19.26,;22.38,-19.26,;21.05,-20.04,;17.07,-23.91,;18.41,-24.68,)|

Structure