Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cannabinoid receptor 2 | ||
| Ligand | BDBM50029964 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1438384 (CHEMBL3383059) | ||
| Ki | 0.680000±n/a nM | ||
| Citation |  Lucchesi, V; Hurst, DP; Shore, DM; Bertini, S; Ehrmann, BM; Allarà, M; Lawrence, L; Ligresti, A; Minutolo, F; Saccomanni, G; Sharir, H; Macchia, M; Di Marzo, V; Abood, ME; Reggio, PH; Manera, C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem57:8777-91 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cannabinoid receptor 2 | |||
| Name: | Cannabinoid receptor 2 | ||
| Synonyms: | CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 39690.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34972 | ||
| Residue: | 360 | ||
| Sequence: |
| ||
| BDBM50029964 | |||
| n/a | |||
| Name | BDBM50029964 | ||
| Synonyms: | CHEMBL3353453 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H33FN4O3 | ||
| Mol. Mass. | 492.585 | ||
| SMILES | CC1CCC(CC1)NC(=O)c1cc2cc(cnc2n(CCN2CCOCC2)c1=O)-c1ccc(F)cc1 |(17.97,-16.85,;16.63,-17.62,;16.64,-19.16,;15.31,-19.93,;13.97,-19.16,;13.96,-17.63,;15.3,-16.86,;12.64,-19.94,;11.31,-19.18,;11.3,-17.64,;9.98,-19.96,;8.64,-19.2,;7.32,-19.97,;5.98,-19.21,;4.65,-19.98,;4.65,-21.52,;5.98,-22.29,;7.32,-21.51,;8.65,-22.28,;8.66,-23.82,;9.99,-24.58,;9.99,-26.12,;8.67,-26.89,;8.67,-28.43,;10,-29.2,;11.33,-28.43,;11.33,-26.89,;9.99,-21.51,;11.32,-22.27,;3.32,-19.21,;3.31,-17.66,;1.97,-16.9,;.64,-17.67,;-.7,-16.9,;.64,-19.22,;1.98,-19.98,)| | ||
| Structure | 
| ||