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TargetCannabinoid receptor 2
LigandBDBM50029965
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1438384
Ki 0.350000±n/a nM
Citation Lucchesi VHurst DPShore DMBertini SEhrmann BMAllarÓ MLawrence LLigresti AMinutolo FSaccomanni GSharir HMacchia MDi Marzo VAbood MEReggio PHManera C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem 57:8777-91 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 2
Name:Cannabinoid receptor 2
Synonyms:CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:39690.94
Organism:Homo sapiens (Human)
Description:P34972
Residue:360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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BDBM50029965
n/a
NameBDBM50029965
Synonyms:CHEMBL3353454
TypeSmall organic molecule
Emp. Form.C26H32N4O4
Mol. Mass.464.5567
SMILESCC1CCC(CC1)NC(=O)c1cc2cc(cnc2n(CCN2CCOCC2)c1=O)-c1ccco1 |(22.89,-5.18,;21.56,-5.95,;21.56,-7.49,;20.23,-8.26,;18.89,-7.49,;18.88,-5.96,;20.22,-5.18,;17.56,-8.27,;16.23,-7.51,;16.22,-5.97,;14.9,-8.28,;13.56,-7.52,;12.24,-8.3,;10.9,-7.53,;9.57,-8.3,;9.57,-9.85,;10.91,-10.62,;12.24,-9.84,;13.57,-10.61,;13.58,-12.14,;14.91,-12.91,;14.91,-14.45,;13.59,-15.22,;13.59,-16.75,;14.92,-17.53,;16.25,-16.76,;16.26,-15.21,;14.91,-9.83,;16.24,-10.6,;8.24,-7.53,;6.83,-8.16,;5.79,-7.02,;6.56,-5.68,;8.07,-6,)|
Structure
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