| Reaction Details |
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 | Report a problem with these data |
| Target | Baculoviral IAP repeat-containing protein 2 |
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| Ligand | BDBM50030280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1439912 (CHEMBL3388612) |
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| IC50 | 15±n/a nM |
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| Citation |  Kim, KS; Zhang, L; Williams, D; Perez, HL; Stang, E; Borzilleri, RM; Posy, S; Lei, M; Chaudhry, C; Emanuel, S; Talbott, R Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists. Bioorg Med Chem Lett24:5022-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Baculoviral IAP repeat-containing protein 2 |
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| Name: | Baculoviral IAP repeat-containing protein 2 |
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| Synonyms: | API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1) | MIHB | RNF48 |
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| Type: | Protein |
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| Mol. Mass.: | 69900.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13490 |
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| Residue: | 618 |
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| Sequence: | MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGV
PVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH
RRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLL
STSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTT
GENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILD
NLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLF
VDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLR
KCPICRGIIKGTVRTFLS
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| BDBM50030280 |
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| n/a |
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| Name | BDBM50030280 |
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| Synonyms: | CHEMBL3339214 | US9783573, Example 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C63H82N10O8 |
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| Mol. Mass. | 1107.3874 |
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| SMILES | CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C |r| |
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| Structure | 
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