| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal alpha-mannosidase |
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| Ligand | BDBM50030340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1432452 (CHEMBL3385734) |
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| IC50 | 252000±n/a nM |
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| Citation |  Markad, PR; Sonawane, DP; Ghosh, S; Chopade, BA; Kumbhar, N; Louat, T; Herman, J; Waer, M; Herdewijn, P; Dhavale, DD ¿-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents. Bioorg Med Chem22:5776-82 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal alpha-mannosidase |
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| Name: | Lysosomal alpha-mannosidase |
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| Synonyms: | LAMAN | MA2B1_HUMAN | MAN2B1 | MANB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 113753.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1432452 |
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| Residue: | 1011 |
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| Sequence: | MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQP
NMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVE
IAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLE
DTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWR
ASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVA
TAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYL
WELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVG
LAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNAL
ARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDP
NGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRS
WSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAY
IFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIP
VGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNT
RIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRG
RHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSV
HLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ
LREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
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| BDBM50030340 |
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| n/a |
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| Name | BDBM50030340 |
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| Synonyms: | CHEMBL3344203 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H23NO4 |
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| Mol. Mass. | 233.3046 |
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| SMILES | CCCCN1C[C@H](O)C(O)(CCO)[C@H](O)C1 |r| |
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| Structure | 
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