| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal alpha-mannosidase |
|---|
| Ligand | BDBM50242271 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1432452 (CHEMBL3385734) |
|---|
| IC50 | 379000±n/a nM |
|---|
| Citation |  Markad, PR; Sonawane, DP; Ghosh, S; Chopade, BA; Kumbhar, N; Louat, T; Herman, J; Waer, M; Herdewijn, P; Dhavale, DD ¿-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents. Bioorg Med Chem22:5776-82 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal alpha-mannosidase |
|---|
| Name: | Lysosomal alpha-mannosidase |
|---|
| Synonyms: | LAMAN | MA2B1_HUMAN | MAN2B1 | MANB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 113753.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1432452 |
|---|
| Residue: | 1011 |
|---|
| Sequence: | MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQP
NMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVE
IAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLE
DTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWR
ASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVA
TAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYL
WELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVG
LAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNAL
ARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDP
NGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRS
WSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAY
IFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIP
VGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNT
RIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRG
RHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSV
HLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ
LREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
|
|
|
|---|
| BDBM50242271 |
|---|
| n/a |
|---|
| Name | BDBM50242271 |
|---|
| Synonyms: | (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol | (2R,3R,4R,5S)-1-ethoxy-2-(hydroxymethyl)piperidine-3,4,5-triol | BAY-M-1099 | CHEMBL1561 | Glyset | MIGLITOL | N-Hydroxyethyl-1-deoxynojirimycin | cid_441314 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H17NO5 |
|---|
| Mol. Mass. | 207.2243 |
|---|
| SMILES | OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
