| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estrogen-related receptor gamma |
|---|
| Ligand | BDBM20608 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1434940 (CHEMBL3385877) |
|---|
| IC50 | 1350±n/a nM |
|---|
| Citation |  Gege, C; Schlüter, T; Hoffmann, T Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. Bioorg Med Chem Lett24:5265-7 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Estrogen-related receptor gamma |
|---|
| Name: | Estrogen-related receptor gamma |
|---|
| Synonyms: | ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 51305.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1501351 |
|---|
| Residue: | 458 |
|---|
| Sequence: | MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGG
SSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYML
NSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSC
QACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSH
LLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL
LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMK
LEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT
LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
|
|
|
|---|
| BDBM20608 |
|---|
| n/a |
|---|
| Name | BDBM20608 |
|---|
| Synonyms: | 4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol | AFIMOXIFENE | CHEMBL489 | [3H]4-OHT | cid_449459 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29NO2 |
|---|
| Mol. Mass. | 387.514 |
|---|
| SMILES | CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
