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TargetPeptidyl-prolyl cis-trans isomerase B
LigandBDBM50339126
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1436363 (CHEMBL3389005)
Kd 7.4±n/a nM
Citation Fu, JTjandra, MBecker, CBednarczyk, DCapparelli, MElling, RHanna, IFujimoto, RFuregati, MKarur, SKasprzyk, TKnapp, MLeung, KLi, XLu, PMergo, WMiault, CNg, SParker, DPeng, YRoggo, SRivkin, ASimmons, RLWang, MWiedmann, BWeiss, AHXiao, LXie, LXu, WYifru, AYang, SZhou, BSweeney, ZK Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. J Med Chem57:8503-16 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase B
Name:Peptidyl-prolyl cis-trans isomerase B
Synonyms:CYP-S1 | CYPB | Cyclophilin B | Cyclophilin B (CypB) | PPIB | PPIB_HUMAN | PPIase | Peptidyl-prolyl cis-trans isomerase B | Rotamase | S-cyclophilin | SCYLP
Type:Protein
Mol. Mass.:23751.82
Organism:Homo sapiens (Human)
Description:P23284
Residue:216
Sequence:
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRV
IFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYG
ERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVR
KVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50339126
n/a
NameBDBM50339126
Synonyms:(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-24-sec-butyl-30-ethyl-33-((1R,2R)-1-hydroxy-2-methylhex-4-enyl)-6,9,18-triisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone | CHEMBL1688529
TypeSmall organic molecule
Emp. Form.C62H111N11O12
Mol. Mass.1202.6112
SMILESCC[C@H](C)[C@@H]1N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC1=O)C(C)C |r|
Structure
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