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TargetPeptidyl-prolyl cis-trans isomerase A
LigandBDBM50030533
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1436352 (CHEMBL3388994)
Kd 1.1±n/a nM
Citation Fu, JTjandra, MBecker, CBednarczyk, DCapparelli, MElling, RHanna, IFujimoto, RFuregati, MKarur, SKasprzyk, TKnapp, MLeung, KLi, XLu, PMergo, WMiault, CNg, SParker, DPeng, YRoggo, SRivkin, ASimmons, RLWang, MWiedmann, BWeiss, AHXiao, LXie, LXu, WYifru, AYang, SZhou, BSweeney, ZK Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. J Med Chem57:8503-16 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase A
Name:Peptidyl-prolyl cis-trans isomerase A
Synonyms:CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A
Type:Protein
Mol. Mass.:18015.32
Organism:Homo sapiens (Human)
Description:P62937
Residue:165
Sequence:
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50030533
n/a
NameBDBM50030533
Synonyms:CHEMBL3344502
TypeSmall organic molecule
Emp. Form.C67H120N12O13
Mol. Mass.1301.7423
SMILES[H][C@@]1([C@H](C)CCN2CCOCC2)N(C)C(=O)[C@@H](C)N(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC1=O)C(C)C |r|
Structure
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