| Reaction Details |
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 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Ligand | BDBM50321274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1437081 (CHEMBL3390812) |
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| IC50 | 6110±n/a nM |
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| Citation |  Mendieta, A; Jiménez, F; Garduño-Siciliano, L; Mojica-Villegas, A; Rosales-Acosta, B; Villa-Tanaca, L; Chamorro-Cevallos, G; Medina-Franco, JL; Meurice, N; Gutiérrez, RU; Montiel, LE; Cruz, Mdel C; Tamariz, J Synthesis and highly potent hypolipidemic activity of alpha-asarone- and fibrate-based 2-acyl and 2-alkyl phenols as HMG-CoA reductase inhibitors. Bioorg Med Chem22:5871-82 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Synonyms: | 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) | HMDH_HUMAN | HMG-CoA Reductase | HMG-CoA reductase (HMGR) | HMGCR |
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| Type: | Enzyme |
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| Mol. Mass.: | 97477.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04035 |
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| Residue: | 888 |
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| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
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| BDBM50321274 |
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| n/a |
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| Name | BDBM50321274 |
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| Synonyms: | CHEMBL1163189 | Methyl 2-(5-hydroxy-2-methoxy-4-propylphenoxy)acetate |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18O5 |
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| Mol. Mass. | 254.279 |
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| SMILES | CCCc1cc(OC)c(OCC(=O)OC)cc1O |
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| Structure | 
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