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TargetBcl-2-like protein 1
LigandBDBM50030751
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1437734 (CHEMBL3382381)
Ki 0.030000±n/a nM
Citation Tao, ZFHasvold, LWang, LWang, XPetros, AMPark, CHBoghaert, ERCatron, NDChen, JColman, PMCzabotar, PEDeshayes, KFairbrother, WJFlygare, JAHymowitz, SGJin, SJudge, RAKoehler, MFKovar, PJLessene, GMitten, MJNdubaku, CONimmer, PPurkey, HEOleksijew, APhillips, DCSleebs, BESmith, BJSmith, MLTahir, SKWatson, KGXiao, YXue, JZhang, HZobel, KRosenberg, SHTse, CLeverson, JDElmore, SWSouers, AJ Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett5:1088-93 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50030751
n/a
NameBDBM50030751
Synonyms:CHEMBL3342334
TypeSmall organic molecule
Emp. Form.C35H31F2N5O4S2
Mol. Mass.687.779
SMILESCN(C)CC#Cc1cc(F)c(OCCCc2sc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)cc1F
Structure
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