Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM50030758 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1437736 (CHEMBL3382383) |
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Ki | 240±n/a nM |
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Citation | Tao, ZF; Hasvold, L; Wang, L; Wang, X; Petros, AM; Park, CH; Boghaert, ER; Catron, ND; Chen, J; Colman, PM; Czabotar, PE; Deshayes, K; Fairbrother, WJ; Flygare, JA; Hymowitz, SG; Jin, S; Judge, RA; Koehler, MF; Kovar, PJ; Lessene, G; Mitten, MJ; Ndubaku, CO; Nimmer, P; Purkey, HE; Oleksijew, A; Phillips, DC; Sleebs, BE; Smith, BJ; Smith, ML; Tahir, SK; Watson, KG; Xiao, Y; Xue, J; Zhang, H; Zobel, K; Rosenberg, SH; Tse, C; Leverson, JD; Elmore, SW; Souers, AJ Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett5:1088-93 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
Type: | Homodimer or heterodimer |
Mol. Mass.: | 26269.11 |
Organism: | Homo sapiens (Human) |
Description: | P10415 |
Residue: | 239 |
Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM50030758 |
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n/a |
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Name | BDBM50030758 |
Synonyms: | CHEMBL3342195 |
Type | Small organic molecule |
Emp. Form. | C40H40N10O4S2 |
Mol. Mass. | 788.94 |
SMILES | CN(C)CCCNc1ncnc2n(ncc12)-c1ccc(OCCCc2sc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)cc1 |
Structure |
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