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TargetBCL-W
LigandBDBM50030754
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1437744
Ki 19±n/a nM
Citation Tao ZFHasvold LWang LWang XPetros AMPark CHBoghaert ERCatron NDChen JColman PMCzabotar PEDeshayes KFairbrother WJFlygare JAHymowitz SGJin SJudge RAKoehler MFKovar PJLessene GMitten MJNdubaku CONimmer PPurkey HEOleksijew APhillips DCSleebs BESmith BJSmith MLTahir SKWatson KGXiao YXue JZhang HZobel KRosenberg SHTse CLeverson JDElmore SWSouers AJ Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett 5:1088-93 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
BCL-W
Name:BCL-W
Synonyms:Apoptosis regulator Bcl-W | Bcl-2-like protein 2 | Bcl2-L-2
Type:Protein
Mol. Mass.:20742.61
Organism:Homo sapiens (Human)
Description:n/a
Residue:193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT
FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG
QVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL
GALVTVGAFFASK
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  Blast E-value cutoff:
BDBM50030754
n/a
NameBDBM50030754
Synonyms:CHEMBL3342332
TypeSmall organic molecule
Emp. Form.C35H32FN5O4S2
Mol. Mass.669.788
SMILESCN(C)CC#Cc1ccc(OCCCc2sc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)c(F)c1
Structure
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