| Reaction Details |
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 | Report a problem with these data |
| Target | Growth hormone secretagogue receptor type 1 |
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| Ligand | BDBM50030788 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1438516 (CHEMBL3385506) |
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| IC50 | >30000±n/a nM |
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| Citation |  Peukert, S; Hughes, R; Nunez, J; He, G; Yan, Z; Jain, R; Llamas, L; Luchansky, S; Carlson, A; Liang, G; Kunjathoor, V; Pietropaolo, M; Shapiro, J; Castellana, A; Wu, X; Bose, A Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett5:1114-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth hormone secretagogue receptor type 1 |
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| Name: | Growth hormone secretagogue receptor type 1 |
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| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
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| Type: | Receptor |
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| Mol. Mass.: | 41334.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
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| Residue: | 366 |
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| Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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| BDBM50030788 |
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| n/a |
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| Name | BDBM50030788 |
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| Synonyms: | CHEMBL3342358 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19ClN6O2S |
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| Mol. Mass. | 418.9 |
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| SMILES | CNc1nc(NCc2ccc(NS(C)(=O)=O)cc2Cl)cc(n1)-c1ccccn1 |
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| Structure | 
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