Ki Summary

Reaction Details

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Target

Bromodomain-containing protein 4

Ligand

BDBM50030927

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1442439 (CHEMBL3380069)

IC50

13000±n/a nM

Citation

McKeown, MR; Shaw, DL; Fu, H; Liu, S; Xu, X; Marineau, JJ; Huang, Y; Zhang, X; Buckley, DL; Kadam, A; Zhang, Z; Blacklow, SC; Qi, J; Zhang, W; Bradner, JE Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem57:9019-27 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Bromodomain-containing protein 4

Name:

Bromodomain-containing protein 4

Synonyms:

BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 | Protein HUNK1

Type:

Protein

Mol. Mass.:

152264.84

Organism:

Homo sapiens (Human)

Description:

O60885

Residue:

1362

Sequence:

MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF

BDBM50030927

n/a

Name

BDBM50030927

Synonyms:

CHEMBL3356137

Type

Small organic molecule

Emp. Form.

C25H27N3O4

Mol. Mass.

433.4996

SMILES

CCCCN1C(c2ccc(-c3c(C)noc3C)c(OC)c2)C(=O)Nc2ccccc2C1=O |(45.11,-15.4,;44.56,-16.84,;45.51,-18.05,;44.95,-19.48,;45.91,-20.68,;45.24,-22.07,;43.7,-22.07,;42.93,-20.74,;41.39,-20.74,;40.62,-22.07,;39.08,-22.07,;38.18,-20.83,;38.65,-19.36,;36.72,-21.3,;36.72,-22.84,;38.18,-23.31,;38.65,-24.78,;41.39,-23.4,;40.62,-24.73,;41.39,-26.07,;42.93,-23.4,;45.91,-23.46,;44.95,-24.66,;47.41,-23.8,;48.61,-22.84,;49.95,-23.61,;51.29,-22.84,;51.29,-21.3,;49.95,-20.53,;48.61,-21.3,;47.41,-20.34,;47.75,-18.84,)|

Structure