| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent neutral amino acid transporter B(0)AT2 |
|---|
| Ligand | BDBM22876 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1432515 (CHEMBL3386947) |
|---|
| IC50 | 4000±n/a nM |
|---|
| Citation |  Cuboni, S; Devigny, C; Hoogeland, B; Strasser, A; Pomplun, S; Hauger, B; Höfner, G; Wanner, KT; Eder, M; Buschauer, A; Holsboer, F; Hausch, F Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. J Med Chem57:9473-9 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent neutral amino acid transporter B(0)AT2 |
|---|
| Name: | Sodium-dependent neutral amino acid transporter B(0)AT2 |
|---|
| Synonyms: | B0AT2 | B0AT2 | NTT73 | S6A15_HUMAN | SBAT1 | SLC6A15 | Sodium- and chloride-dependent neurotransmitter transporter NTT73 | Sodium-coupled branched-chain amino-acid transporter 1 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Solute carrier family 6 member 15 | Transporter v7-3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 81820.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_109513 |
|---|
| Residue: | 730 |
|---|
| Sequence: | MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE
RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS
VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD
QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC
LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR
EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA
NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA
LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE
GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE
NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN
AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG
RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD
IMPDMPESDL
|
|
|
|---|
| BDBM22876 |
|---|
| n/a |
|---|
| Name | BDBM22876 |
|---|
| Synonyms: | CHEMBL998 | Claritin | Loratadine | Sch 29851 | US9138431, LORATADINE (Claritin) | US9333199, LORATADINE (Claritin) | ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23ClN2O2 |
|---|
| Mol. Mass. | 382.883 |
|---|
| SMILES | [#6]-[#6]-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 |
|---|
| Structure | 
|
|---|
Search and Browse
