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TargetDeoxycytidine kinase
LigandBDBM50440172
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1437136
Ki 0.500000±n/a nM
Citation Nomme JLi ZGipson RMWang JArmijo ALLe TPoddar SSmith TSantarsiero BDNguyen HACzernin JAlexandrova ANJung MERadu CGLavie A Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. J Med Chem 57:9480-94 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxycytidine kinase
Name:Deoxycytidine kinase
Synonyms:dCK
Type:PROTEIN
Mol. Mass.:30510.65
Organism:Homo sapiens (Human)
Description:ChEMBL_1437135
Residue:260
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL
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  Blast E-value cutoff:
BDBM50440172
n/a
NameBDBM50440172
Synonyms:CHEMBL2426574
TypeSmall organic molecule
Emp. Form.C21H28N6O4S3
Mol. Mass.524.68
SMILESCCCc1sc(nc1CSc1nc(N)cc(N)n1)-c1ccc(OC)c(OCCNS(C)(=O)=O)c1
Structure
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