Reaction Details |
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Target | Malate dehydrogenase, mitochondrial |
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Ligand | BDBM50031516 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1440890 (CHEMBL3374593) |
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IC50 | >20000±n/a nM |
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Citation | Naik, R; Won, M; Ban, HS; Bhattarai, D; Xu, X; Eo, Y; Hong, YS; Singh, S; Choi, Y; Ahn, HC; Lee, K Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1a/malate dehydrogenase 2 inhibitors. J Med Chem57:9522-38 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Malate dehydrogenase, mitochondrial |
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Name: | Malate dehydrogenase, mitochondrial |
Synonyms: | MDH2 | MDHM_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 35512.45 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1456625 |
Residue: | 338 |
Sequence: | MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
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BDBM50031516 |
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n/a |
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Name | BDBM50031516 |
Synonyms: | CHEMBL3359143 |
Type | Small organic molecule |
Emp. Form. | C34H33NO4 |
Mol. Mass. | 519.6301 |
SMILES | O=C(COc1ccc(cc1)C12CC3CC(CC(C3)C1)C2)Nc1cccc(c1)C(=O)c1ccc(OCC#C)cc1 |TLB:7:10:13.12.17:15,THB:11:12:15:19.10.18,11:10:13.12.17:15,18:10:13:17.16.15,18:16:13:19.11.10| |
Structure |
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