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TargetMalate dehydrogenase, mitochondrial
LigandBDBM50031517
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1440890 (CHEMBL3374593)
IC50>20000±n/a nM
Citation Naik, RWon, MBan, HSBhattarai, DXu, XEo, YHong, YSSingh, SChoi, YAhn, HCLee, K Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1a/malate dehydrogenase 2 inhibitors. J Med Chem57:9522-38 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Malate dehydrogenase, mitochondrial
Name:Malate dehydrogenase, mitochondrial
Synonyms:MDH2 | MDHM_HUMAN
Type:PROTEIN
Mol. Mass.:35512.45
Organism:Homo sapiens (Human)
Description:ChEMBL_1456625
Residue:338
Sequence:
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50031517
n/a
NameBDBM50031517
Synonyms:CHEMBL3359144
TypeSmall organic molecule
Emp. Form.C35H33NO4
Mol. Mass.531.6408
SMILESO=C(Nc1cccc(c1)C(=O)c1ccc(OCC#C)cc1)\C=C\Oc1ccc(cc1)C12CC3CC(CC(C3)C1)C2 |TLB:27:30:33.32.37:35,THB:31:32:35:39.30.38,31:30:33.32.37:35,38:30:33:37.36.35,38:36:33:39.31.30|
Structure
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