| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 5 |
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| Ligand | BDBM50031747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1432592 (CHEMBL3388151) |
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| IC50 | >10000±n/a nM |
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| Citation |  Menet, CJ; Fletcher, SR; Van Lommen, G; Geney, R; Blanc, J; Smits, K; Jouannigot, N; Deprez, P; van der Aar, EM; Clement-Lacroix, P; Lepescheux, L; Galien, R; Vayssiere, B; Nelles, L; Christophe, T; Brys, R; Uhring, M; Ciesielski, F; Van Rompaey, L Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634. J Med Chem57:9323-42 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 5 |
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| Name: | MAP kinase-activated protein kinase 5 |
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| Synonyms: | MAP kinase-activated protein kinase 5 (PRAK) | MAPK-Activated Protein Kinase 5 (MK5) | MAPK-activated protein kinase 5 | MAPK5_HUMAN | MAPKAP kinase 5 | MAPKAPK5 | PRAK | p38-regulated/activated protein kinase | p38-regulated/activated protein kinase (PRAK) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 54229.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant MAPKAPK5 was phosphorylated by incubation with active p38alpha before assays. |
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| Residue: | 473 |
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| Sequence: | MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQ
EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
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| BDBM50031747 |
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| n/a |
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| Name | BDBM50031747 |
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| Synonyms: | CHEMBL3360318 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N4O2 |
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| Mol. Mass. | 308.3345 |
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| SMILES | COc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 |
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| Structure | 
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