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TargetPolycomb protein EED
LigandBDBM24226
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1437166 (CHEMBL3382328)
Ki 23010±n/a nM
Citation Kong, XChen, LJiao, LJiang, XLian, FLu, JZhu, KDu, DLiu, JDing, HZhang, NShen, JZheng, MChen, KLiu, XJiang, HLuo, C Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2. J Med Chem57:9512-21 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polycomb protein EED
Name:Polycomb protein EED
Synonyms:EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:Protein
Mol. Mass.:50201.68
Organism:Homo sapiens (Human)
Description:O75530
Residue:441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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  Blast E-value cutoff:
BDBM24226
n/a
NameBDBM24226
Synonyms:1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine | ASTEMIZOLE | Astemizole, [O-Methyl-3H] | CHEMBL296419 | Hismanal | Histaminos | [3H]-ASTEMIZOLE | [3H]Astemizole | cid_2247 | med.21724, Compound Astemizole
TypeRadiolabeled ligand
Emp. Form.C28H31FN4O
Mol. Mass.458.5703
SMILESCOc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1
Structure
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