| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM50032274 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1440125 |
|---|
| Ki | 900±n/a nM |
|---|
| Citation |  Maolanon AR; Villadsen JS; Christensen NJ; Hoeck C; Friis T; Harris P; Gotfredsen CH; Fristrup P; Olsen CA Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles. J Med Chem 57:9644-57 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 2 |
|---|
| Name: | Histone deacetylase 2 |
|---|
| Synonyms: | HD2 | HDAC2 | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 55356.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The assay was performed using isolated HDAC2 that had been expressed as full-length 6x His-tagged fusion proteins in a baculovirus expression system in Sf9 cells. |
|---|
| Residue: | 488 |
|---|
| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
|---|
| BDBM50032274 |
|---|
| n/a |
|---|
| Name | BDBM50032274 |
|---|
| Synonyms: | CHEMBL3352996 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H36N4O6 |
|---|
| Mol. Mass. | 500.5872 |
|---|
| SMILES | CC(C)[C@H]1NC(=O)C[C@@H](C\C=C/CCC(O)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
